Dr. Jason Hansen
Birth defects are the leading contributor to infant mortality during the first year of life. Unfortunately, the mechanistic origins of most birth defects remain largely unknown. Recent research suggests, however, that certain teratogens elicit their harmful effects primarily through oxidative stress. I study how manipulation of specific antioxidant pathways combats teratogen-induced redox disruptions, decreasing the prevalence of birth defects in the developing embryo.